<p>MicroRNA-218 regulates the chemo-sensitivity of cervical cancer cells through targeting survivin</p>
نویسندگان
چکیده
منابع مشابه
MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis...
متن کاملMiR-218 increases sensitivity to cisplatin in esophageal cancer cells via targeting survivin expression
OBJECTIVES Increasing evidence showed that microRNAs (miRNAs) were implicated in the chemical resistance of human cancers. We intended to investigate the role of miR-218 in cisplatin sensitivity of esophageal cancer cells. METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to analyze miR-218 expression in human esophageal cancer cell line Eca9706 and a cisplati...
متن کاملMicroRNA-21 Regulates Non-Small Cell Lung Cancer Cell Invasion and Chemo-Sensitivity through SMAD7.
BACKGROUND/AIMS SMAD7 is a key inhibitor of transforming growth factor β (TGFβ) receptor signaling, which regulates the alteration of cancer cell invasiveness through epithelial-mesenchymal cell conversion. Carboplatin is a commonly used drug in the chemotherapy for non-small cell lung cancer (NSCLC). Nevertheless, the molecular mechanisms underlying its suppressive effects on the NSCLC cell in...
متن کاملMicroRNA-218 Increases the Sensitivity of Bladder Cancer to Cisplatin by Targeting Glut1.
BACKGROUND/AIMS MicroRNA-218 (miR-218) is down-regulated in many malignancies that have been implicated in the regulation of diverse processes in cancer cells. However, the involvement of miR-218 in chemo-sensitivity to cisplatin and the precise mechanism of this action remained unknown in bladder cancer. METHODS qRT-PCR was used to detect miR-218 and its target Glut1 expression in bladder ca...
متن کاملtargeting gastric cancer stem cells through developmental pathways: hypothesis
cancer stem cells (cscs) have been defined as a unique subpopulation in tumors, endowed with the capacity to initiate tumor progression, maintain self-renewal as well as metastatic potential. recently, more evidence strongly indicates the existence of cscs in solid tumors of wide variety of organs such as breast, brain and stomach. recent studies suggest that a special subpopulation of gastric ...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2019
ISSN: 1179-1322
DOI: 10.2147/cmar.s199659